ADLD is caused by an extra copy of the LMNB1 gene, which leads to overproduction of the Lamin B1 protein in the body. Understanding the genetics behind diseases like ADLD is key to developing potential treatments.
There are about 21,000 protein-coding genes in the human genome. Genes provide instructions for making proteins by first creating messenger RNA (mRNA) transcripts. In ADLD, the duplicated LMNB1 gene generates too many mRNA transcripts, resulting in excess Lamin B1 protein production.
Researchers believe that if they can reduce activity of the duplicated gene, lower mRNA transcript levels, or decrease the amount of Lamin B1 protein, they may be able to stop ADLD progression. Over the years, scientists have developed several techniques to treat genetic diseases, though many are still in early research stages.
One approved approach is antisense oligonucleotide therapy, which works by seeking out and destroying specific mRNA transcripts to dramatically reduce levels of harmful proteins. Please check the following website for more details. Though developing any new therapy takes extensive testing and clinical trials, antisense technology provides hope for future ADLD treatments.
ADLD Community Shares Healthy Living Tips
In addition to scientific advances, the ADLD community has wisdom to share on living well with the disease. Many recommend safe exercise like walking in a pool, with guidance from a doctor or physical therapist. Eating a balanced, hydrating diet with probiotics can also help maintain energy and digestion. The ADLD Center welcomes any other tips people are willing to share!
By understanding the science behind diseases and learning from one another, we can continue making progress against ADLD. The Center strives to keep the community informed on the latest research as well as practical ways to support health and wellbeing.